The JSH Single Topic Conference:  NASH-2010

(Oct 21, updated)

【Day 1】8:30 -
Opening Remarks       8:30-8:40                                                     (10 min)         
Sumio Watanabe (Chairman of the Conference)    

Session 1 Disease Definition and Epidemiological Issues  8:40-10:00  (80 min)
Chair: Yutaka Kogo (Japan), Arun Sanyal (USA)
1. World trend of NAFLD/NASH (20 min)
Arun Sanyal (USA)
2. Epidemiology of NAFLD/NASH in Japan (20 min)
Norihito Watanabe (Japan)
3. Genetic Predisposition to NAFLD/NASH (20 min)
Toshiji Saibara (Japan) 
4. NASH in Children (20 min)
Valerio Nobili (Italy)

Coffee Break                                                               10:00-10:10         (10 min)

Session 2 Clinco-pathological Diagnosis Update        10:10-11:30     (80 min)
           Chair: Yutaka Aoyagi (Japan), Satoshi Mochida (Japan)
1. Clinco-pathological Diagnosis of NAFLD/NASH                  (20 min)
Etsuko Hashimoto (Japan)
2. Pathological Diagnosis and Scoring Systems                       (20 min)
Yasuni Nakanuma (Japan)
3. Non-invasive Diagnosis of NAFLD/NASH (tentative) (20 min)
Atsushi Nakajima (Japan)
4. Clinical Scoring Systems for NAFLD/NASH          (20 min)             
Yoshio Sumida (Japan)

Distinguished Poster Presentation     1        11:30-12:00                (30 min)
Chair: Hidetsugu Saito (Japan)
1. Tomonori Aoyama (Japan) (10 min)
2. Nobuko Serizawa (USA) (10 min)
3. Juliane I Beier (USA) (10 min)

Luncheon Seminar 1  (Ajinomoto-Pharmaceutical Co., Ltd. presents)          12:05-12:50   (45 min)
Chair: Kazuhiko Koike (Japan)
Diabetes and Liver Disorder: Ryuzo Kawamori (Japan)

Session 3         Metabolic Abnormalities in NAFLD/NASH 13:00-14:00         (60 min)
Chair: Yoshiyuki Takei (Japan), Stephen Caldwell (USA)
1. NAFLD as a Liver Manifestation of Metabolic Syndrome (20 min)
Stephen Caldwell (USA)
2. Insulin Resistance and NAFLD/NASH (20 min)
Kojiro Ueki (Japan)
3. Lipid Metabolism in NAFLD/NASH (20 min)
Makoto Nakamuta (Japan)

Special Lecture 1                              14:00-14:45                           (45 min)
Chair: Sumio Watanabe (Japan)
Toll-like Receptors in the Pathogenesis of NAFLD/NASH                   
David Brenner (USA)

Coffee Break & Poster Viewing/Discussion                14:45-15:45                (60 min)

Session 4 Immunity and Cytokine Responses in NASH        15:45-17:05   (80 min)
Chair: Morikazu Onji (Japan), Tetsuo Takehara (Japan)
1. Innate Immunity and NAFLD/NASH                  (20 min)
Kenichi Ikejima (Japan)
2. Adipokine Expression in NAFLD/NASH Patients                (20 min)
Yong Kyun Cho (Korea)
3. Adipokine Regulation in Steatohepatitis                             (20 min)
Yoshihiro Kamada (Japan)
4. Cytokine Regulation in NASH (20 min)
Takato Ueno (Japan)

Evening Seminar (MSD K.K. presents)                     17:15-18:00                (45 min)
Chair: Hajime Takikawa (Japan)
HCV and Hepatic Steatosis: Kyoji Moriya (Japan)

Conference Welcome Reception                      18:00-20:00

【Day 2】
Morning Seminar (Eisai Co., Ltd. presents)              8:00-8:45        (45 min)
Chair: Kazuhide Yamamoto (Japan)
Epigenetic Regulation of Hepatic Stellate Cells                                    
Hide Tsukamoto (USA)

Session 5         Hepatic Fibrogenesis in NASH                      8:45-10:05       (80 min)
Chair: Norifumi Kawada (Japan), Natalie Torok (USA)
1. Molecular Mechanisms of Hepatic Stellate Cell Activation (20 min)
Yutaka Inagaki (Japan)
2. Rennin-Angiotensin System in Hepatic Fibrogenesis          (20 min)
Hitoshi Yoshiji (Japan)    
3. Apoptosis and Hepatic Fibrogenesis (20 min)
Natalie Torok (USA)
4. Hepatic Fibrogenesis in Animal Models of NASH (20 min)
Hideki Fujii (Japan)

Coffee Break                          10:05-10:15                (10 min)

Session 6         Hepatic Carcinogenesis in NASH                  10:15-11:35     (80 min)
Chair: Fuminori Moriyasu (Japan), Isao Sakaida (Japan)
1. Hepatic Carcinogenesis in NASH Patients in Japan (20 min)
Katsutoshi Tokushige (Japan)
2. Retinoid Metabolism and Hepatic Carcinogenesis (20 min)
Goshi Shiota (Japan)
3. Carcinogenesis in Animal Models of NASH (20 min)
Yasuo Horie (Japan)
4. Prevention of Hepatocellular Carcinoma in NASH (20 min)
JG Fan (China)

Distinguished Poster Presentation     2                   11:35-12:05                (30 min)
Chair: Masashi Yoneda (Japan)
1. Naoki Fujita (Japan) (10 min)
2. Yoichi Hiasa (Japan) (10 min)
3. Kosuke Okada (Japan) (10 min)

Luncheon Seminar 2 (Otsuka Pharmaceutical Co., Ltd. presents) 12:10-12:55         (45 min)
           Chair: Hirohito Tsubouchi (Japan)
NASH Survey in Japan
Takeshi Okanoue (Japan)

Session 7         Cellular Stress Responses in NAFLD/NASH  13:00-14:20  (80 min)
Chair: Yutaka Sasaki (Japan), Gavin Arteel (USA)
1. Oxidative Stress in the Pathogenesis of NAFLD/NASH (20 min)
Gavin Arteel (USA)
2. Iron Metabolism and NAFLD/NASH (20 min)
Takaaki Ohtake (Japan)
3. Autophagy in NASH (20 min)
Takashi Ueno (Japan)
4. Mechanism of Mallory Body Formation in NASH (20 min)
Masaru Harada (Japan)
Special Lecture 2                                          14:20-15:05                (45 min)
Chair: Michio Imawari (Japan)
Role of Proteolysis in Liver Pathophysiology
Keiji Tanaka (Japan)

Coffee break                                                                15:05-15:15                       (10 min)

Session 8         Therapeutic Approach for NAFLD/NASH       15:15-17:55     (100 min)
Chair: Sumio Kawada (Japan), Vlad Ratziu (France)
1. Current Clinical Evidence for the Treatment of NAFLD/NASH (20 min)
Vlad Ratziu (France)
2. Non-invasive Evaluation Methods for NAFLD/NASH        (20 min)
Kieth Lindor (USA)
3. Dietary Restriction and Exercise for Prevention/treatment of NAFLD/NASH              (20 min)             
Toshinari Takamura (Japan)
4. Treatment of NAFLD/NASH in China  (20 min)
Lu Fuer (China)
5. Treatment of NAFLD/NASH in Japan  (20 min)
Hideyuki Hyogo (Japan)
Closing Remarks: Sumio Watanabe (Chairman of the Conference)    17:55-18:00               
Adjourn